Journal
ORGANIC LETTERS
Volume 6, Issue 4, Pages 557-560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol036341+
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- NCRR NIH HHS [1 S10 RR08389-01] Funding Source: Medline
- NIGMS NIH HHS [T32 GM 08505] Funding Source: Medline
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Poly(1) kills bacteria (Gram-positive and -negative) and lyses human erythrocytes; this biocidal profile is similar to that of the peptide toxin mellitin. Poly(1) has antibacterial activity comparable to that of a potent derivative of the host defense peptide magainin II, but lacks magainin's selectivity for bacteria over erythrocytes. An analogous N-quaternized polymer, poly(3), is less biocidal than poly(1), suggesting that reversible N-protonation leads to greater biocidal activity than does irreversible N-quaternization.
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