Journal
NEUROSCIENCE LETTERS
Volume 356, Issue 3, Pages 191-194Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.11.049
Keywords
D,L-2-amino-5-phosphonopentanoic acid; microinjection; object recognition; perirhinal cortex; rats; scopolamine
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To determine the possible involvement of N-methyl-D-aspartate (NMDA) and muscarinic activation of the perirhinal cortex in object recognition, an NMDA antagonist (D,L-2-amino-5-phosphonopentanoic acid (AP5)) and a muscarinic antagonist (scopolamine) were injected into the perirhinal cortex of rats. A high dose of AP5 (60 mM) and two doses of scopolamine (20 and 80 mM), but not a low dose of AP5 (30 mM) alone, significantly impaired discrimination between novel and familiar objects in a spontaneous object recognition task, which is one of the recognition memory tasks. These results suggest that activation of both NMDA and muscarinic receptors in the perirhinal cortex contributes to object recognition. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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