Journal
SCIENCE
Volume 303, Issue 5661, Pages 1182-1185Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1092938
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R37-GM30702, R01 GM030702, F32 GM065007, F32-GM065007] Funding Source: Medline
Ask authors/readers for more resources
To achieve X-chromosome dosage compensation, organisms must distinguish X chromosomes from autosomes. We identified multiple, cis-acting regions that recruit the Caenorhabditis elegans dosage compensation complex (DCC) through a search for regions of X that bind the complex when detached from X. The DCC normally assembles along the entire X chromosome, but not all detached regions recruit the complex, despite having genes known to be dosage compensated on the native X. Thus, the DCC binds first to recruitment sites, then spreads to neighboring X regions to accomplish chromosome-wide gene repression. From a large chromosomal domain, we defined a 793-base pair fragment that functions in vivo as an X-recognition element to recruit the DCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available