Design and synthesis of new macrocyclic cyclophanes using 1,3-dioxane units as bridges:: A molecular rocking chair

The design, synthesis and structural analysis of architecturally new cyclophanes (monomers, dimers, and trimers) are reported. Variable temperature NMR experiments reveal a regular, tandem dynamic in the cyclophane 2a that enables its description as a molecular rocking chair. The NMR and X-ray structure investigations show important intra- and intermolecular aromatic pi-stacking interactions.