Journal
LANCET
Volume 363, Issue 9409, Pages 619-622Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(04)15596-7
Keywords
-
Categories
Funding
- NCRR NIH HHS [RR0772] Funding Source: Medline
- NIAID NIH HHS [AI07140, AI35039, AI37984, AI47734, AI35040, AI49755, AI35042, AI35041] Funding Source: Medline
Ask authors/readers for more resources
Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per muL was very rapid (<3.4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available