4.4 Article

The first total synthesis and determination of the absolute configuration of chapecoderin A, B and C

Journal

TETRAHEDRON
Volume 60, Issue 9, Pages 1983-1989

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.01.004

Keywords

total synthesis; labdane diterpenoid; absolute stereochemistry

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The seco- and rearranged-labdanes, chapecoderins A 1, B 2, and C 3 have been synthesized for the first time starting from (S)-(+)-Wieland-Miescher ketone analogue 11. Their absolute configurations have been determined as depicted in the structures 1, 2 and 3. (C) 2004 Elsevier Ltd. All rights reserved.

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