Journal
NEUROLOGY
Volume 62, Issue 4, Pages 624-627Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.62.4.624
Keywords
-
Categories
Funding
- NIBIB NIH HHS [EB01015] Funding Source: Medline
- NINDS NIH HHS [NS37739, NS29029] Funding Source: Medline
Ask authors/readers for more resources
Global brain atrophy estimated using MRI and whole brain N-acetylaspartate (WBNAA) concentration measured with proton MR spectroscopy were obtained in 42 patients with relapsing-remitting multiple sclerosis and 41 matched control subjects. Patients exhibited cross-sectional atrophy (9.5%; p = 0.033) and WBNAA decline (1.8%/y; p = 0.005) vs disease duration. The 3.6-fold rate disparity between the two processes suggests that neuronal/axonal dysfunction (N-acetylaspartate decline) precedes parenchyma loss, not its consequence (i.e., is an earlier, more sensitive specific metric of the ongoing disease activity).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available