Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume 36, Issue 1, Pages 13-22Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emm.2004.2
Keywords
autoimmune diseases; Behcet syndrome; biological markers; lupus erythematosus systemic; rheumatoid arthritis; serum
Funding
- NEI NIH HHS [R01 EY 13325] Funding Source: Medline
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Rheumatoid arthritis (RA) is a multifactorial autoimmune disease whose etiopathogenesis is not well understood. Although soluble (s) forms of 4-1BB (s4-1BB) and 4-1BB legand (s4-1BBL) have been detected in the sera of RA patients, their significance is not known. We compared the serum levels of s4-1BB and s4-1BBL in RA patients with those in systemic lupus erythematosus (SLE) and Behicet's disease (BID) patients. Serum levels of s4-1BB and s4-1BBL were significantly higher in RA patients compared with healthy controls, SLE or 131) patients, and the abundance was correlated with disease severity in patients with RA. The serum levels of s4-1BBL in RA patients were inversely corroborated with 4-1BB expression levels on activated T lymphocytes. In addition, there was a correlation between serum levels of s4-1BB and s4-1BBL. The augmented secretion of s4-1BB and s4-1BBL levels into the serum may reflect the clinical symptoms of RA and levels of s4-1BB and s4-1BBL in sera at the time of diagnosis may be indicative of the severity and outcome of RA.
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