Journal
LEUKEMIA RESEARCH
Volume 28, Issue 3, Pages 285-294Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0145-2126(03)00264-9
Keywords
Bcr-Abl; Philadelphia chromosome; chronic myelogenous leukemia; acute lymphocytic leukemia; interferon-gamma-inducible GTPases; microarray analysis
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Funding
- NCI NIH HHS [CA61033] Funding Source: Medline
- NHLBI NIH HHS [2-T32-HC07057-26] Funding Source: Medline
- NIAID NIH HHS [R01 AI057831] Funding Source: Medline
- NIA NIH HHS [AG11268] Funding Source: Medline
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p185 Bcr-Abl has a more aggressive biological/clinical leukemia phenotype than p210 Bcr-Abl. In this study, we examined differential gene expression using microarrays to determine if Upregulation or downregulation of specific genes may explain the distinct phenotypes produced by the two Bcr-Abl forms. RNA was collected from mouse bone marrow mononuclear cells expressing equivalent levels of p 185 or p210, and the RNAs were subjected to microarray analysis. significant differences in gene expression were observed on hierarchical clustering. A group of interferon-gamma-inducible genes, including those encoding a family of 47 kDa GTPases, were significantly increased in p185 versus p210. This family of GTPases has previously been implicated in interferon-gamma-induced resistance against intracellular pathogens, however their exact cellular functions are unknown. Our data Suggest that their increased expression may contribute to the biological/clinical phenotype associated with p185. (C) 2003 Elsevier Ltd. All rights reserved.
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