Journal
JOURNAL OF BACTERIOLOGY
Volume 186, Issue 5, Pages 1574-1578Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.5.1574-1578.2004
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Funding
- NIAID NIH HHS [R01 AI055987, 5R01AI055987-02] Funding Source: Medline
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Vibrio cholerae switches between smooth and rugose colonial variants. The rugose variant produces more vibrio polysaccharides (VPSEl Tor) and forms well-developed biofilms. Both phenotypes depend on expression of vps biosynthesis genes. We identified a positive transcriptional regulator of vps gene expression, VpsT, which is homologous to response regulators of two-component regulatory systems. Disruption of vpsT in the rugose variant yields smooth colonies, prevents formation of mature biofilms, and decreases vps gene expression. The interaction between VpsT and VpsR, a previously identified positive regulator of vps genes, was also investigated.
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