Journal
NEUROCHEMICAL RESEARCH
Volume 29, Issue 3, Pages 637-650Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/B:NERE.0000014834.06405.af
Keywords
amyloid beta peptide; intracellular calcium; oxidative stress; mitochondria; NADPH oxidase
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Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta (Abeta) peptides. Although the disease undoubtedly reflects the interaction of complex multifactorial processes, Abeta itself is toxic to neurons in vitro and the load of Abeta in vivo correlates well with the degree of cognitive impairment. There has therefore been considerable interest in the mechanism(s) of Abeta neurotoxicity. We here review the basic biology of Abeta processing and consider some of the major areas of focus of this research. It is clear that both AD and Abeta toxicity are characterized by oxidative stress, alterations in the activity of enzymes of intermediary metabolism, and mitochondrial dysfunction, especially impaired activity of cytochrome c oxidase. Studies in vitro also show alterations in cellular calcium signaling. We consider the mechanisms proposed to mediate cell injury and explore evidence to indicate which of these many changes in function are primary and which secondary.
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