Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 58, Issue 3, Pages 927-931Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2003.09.092
Keywords
EGFR; gliomas; radiation
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Purpose: The epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII). Methods and Materials: This review highlights EGFR's role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data. Results: Preclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas. Conclusions: Targeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients. (C) 2004 Elsevier Inc.
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