Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 4, Issue 3, Pages 403-409Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2003.12.015
Keywords
Agaricus blazei Murill; hepatitis B core antigen; DNA vaccine
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DNA vaccines induce protective humoral and cell-mediated immune responses in several animal models. Agaricus blazei Murill (ABM) is particularly rich in polysaccharides, and has shown particularly strong results in treating and preventing cancers. The goal of this study was to investigate whether coimmunization of the fungus ABM with hepatitis B virus (HBV) core DNA vaccine could increase the immune responses. Compared with the control mice which received hepatitis B virus core antigen (HBcAg) alone, significant increase in not only the HBcAg-specific antibody response but also T cell proliferation was observed in mice which received HBcAg DNA vaccine plus ABM extract. These results suggest that ABM extract might represent an adjuvant to improve the efficacy of DNA vaccines in vivo. (C) 2004 Elsevier B.V. All rights reserved.
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