Journal
PROTEOMICS
Volume 4, Issue 3, Pages 629-632Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pmic.200300572
Keywords
glycosylation; mass spectrometry; N-linked glycane; tandem mass spectrometry
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A software tool, Sweet Substitute, is described, which assists tandem mass spectrometry (MS/MS)-based glycosylation characterization from within a tryptic digest. The algorithm creates a virtual nanoelectrospray-quadrupole time-of-flight style-MS/MS spectrum of any user-defined N-linked glycan structure. An empirical peak height modeling routine is implemented in the program. By comparing the theoretical MS/MS data with the deconvoluted and deisotoped experimental MS/MS data, the user is able to quickly assess whether a proposed candidate oligosaccharide structure is a plausible one.
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