Journal
REVUE DE MEDECINE INTERNE
Volume 25, Issue 3, Pages 225-229Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.revmed.2003.10.015
Keywords
aortitis; G-CSF; side effects; Horton's disease
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Introduction.-Aortitis consists in aortic wall inflammation from infectious or non infectious cause. It may lead to aortic aneurysm with a risk of rupture. which is life-threatening and may justify surgical procedures. The cause of the aortitis is sometimes obscure. Case report.-We report the case of a 55 years old woman who developed acute aortitis of the descending aorta after G-CSF (granulocyte-colony stimulating factor) injections for blood stem cells graft. No cause was found to the aortitis, the evolution was favorable after corticosteroid treatment, without aneurysm at six months. Conclusion.-The present case rises the question of G-CSF (Neupogen(R)) responsibility in aortic lesions. Neutrophilic mediated diseases (Sweet's syndrome, pyoderma gangrenosum) and leukocytoclastic vasculitis were reported after G-CSF therapy. Neutrophils induced by G-CSF injections present functional abnormalities which may play a role in the pathogenesis of these diseases. (C) 2003 Elsevier SAS. Tous droits reserves.
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