Journal
BIOLOGICAL PSYCHIATRY
Volume 55, Issue 5, Pages 531-537Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.09.011
Keywords
substance-related disorders; heroin dependence; decision making; choice behavior; impulsivity; personality
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Funding
- NIDA NIH HHS [R29 DA 11721] Funding Source: Medline
- NIMH NIH HHS [R01 MH066031] Funding Source: Medline
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Background: Healthy individuals performing response suppression tasks activate anterior cingulate cortex with occurrence of false alarm error responses to nontargets. Fundamental questions include whether this error-related activation provides a signal contributing to behavioral control and given generally poorer performance on such tasks by addicts, whether this signal is disrupted in addiction. Methods: We used rapid, event-related functional magnetic resonance imaging to study 13 individuals with opiate dependence and 26 healthy control individuals performing a Go/NoGo task. Results: Compared with controls, opiate addicts exhibited an attenuated anterior cingulate cortex error signal and significantly poorer task performance. In controls, the individual level of event-related anterior cingulate cortex activation accompanying false alarm error positively predicted task performance, particularly sensitivity in discriminating targets from nontargets. Conclusions: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior.
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