Journal
EXPERIMENTAL GERONTOLOGY
Volume 39, Issue 3, Pages 433-441Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2004.01.001
Keywords
Alzheimer's disease; olfaction; apolipoprotein; memory; recognition; aging
Categories
Funding
- NIA NIH HHS [R01 AG004085, AG04085] Funding Source: Medline
- NIDCD NIH HHS [DC00032] Funding Source: Medline
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Recognition and remote memory for olfactory and visual stimuli were assessed in nondemented elderly individuals positive for the apolipoprotein E epsilon4 allele and in epsilon4 negative controls to examine whether the epsilon4 allele differentially affects recognition and/or remote memory depending on the modality of stimulus to be remembered. Compared to controls, epsilon4 positive individuals committed more false positive recognition memory errors for olfactory but not visual stimuli suggesting that epsilon4 positive individuals may show false positive errors for olfactory Stimuli before deficits for other stimuli are detectable. There were no significant differences in familiarity ratings (a proposed measure of remote memory) suggesting that brain areas involved in remote memory are not affected in nondemented FA positive individuals. The results suggest that neuropathological changes in nondemented individuals genetically at risk for Alzheimer's disease may differentially affect memory processes. (C) 2004 Published by Elsevier Inc.
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