Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 63, Issue 29, Pages 6633-6643Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b02105
Keywords
mycotoxins; dietary supplements; milk thistle; ultraperformance liquid chromatography; tandem mass spectrometry; standard addition method
Funding
- European Union [EP7/CSA/KBBE.2010.2.6-01, 266061]
- EC
- Operational Program Prague - Competitivness [CZ.2.16/3.1.00/22197]
- National Program of Sustainability (NPU I (LO)) [MSMT - 34870/2013]
- Ministry of Education, Youth and Sports of the Czech Republic [AMVIS LH11059]
- European Union [EP7/CSA/KBBE.2010.2.6-01, 266061]
- EC
- Operational Program Prague - Competitivness [CZ.2.16/3.1.00/22197]
- National Program of Sustainability (NPU I (LO)) [MSMT - 34870/2013]
- Ministry of Education, Youth and Sports of the Czech Republic [AMVIS LH11059]
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Mycotoxin contamination of dietary supplements represents a possible risk for human health, especially in the case of products intended for people suffering from certain health conditions. The aim of this study was to assess the extent of this problem based on-analyses of a wide set of herbal-based dietary supplements intended for various purposes: (1) treatment of liver diseases (milk thistle); (ii) reduction of menopause effects (red clover, flax seed, and soy); and (iii) preparations for general health support (green barley, nettle, goji berries, yucca, etc.) The analytical method including 57 mycotoxins was based on a QuEChERS-like (quick, easy, cheap, effective, rugged, safe) approach and ultrahigh performance liquid chromatography coupled with tandem mass spectrometry. The main mycotoxins determined were Fusarium trichothecenes, zearalenone and enniatins, and Alternaria mycotoxins. Co-occurrence of enniatins, HT-2/T-2 toxins, and Alternaria toxins was observed in many cases. The highest mycotoxin concentrations were found in milk thistle-based supplements (up to 37 mg/kg in the sum).
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