Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 113, Issue 6, Pages 788-794Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200421357
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Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
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