Journal
PURE AND APPLIED CHEMISTRY
Volume 76, Issue 3, Pages 465-475Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/pac200476030465
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Asymmetric 1,4-arylation and -alkenylation was achieved by use of organoboronic acids or their derivatives in the presence of a rhodium catalyst coordinated with binap or its related ligands. The scope of this asymmetric addition is very broad, alpha,beta-unsaturated ketones. esters, amides, 1-alkenylphosphonates, and 1-nitroalkenes being efficiently converted into the corresponding 1,4-addition products with over 95% enantioselectivity. The catalytic cycle in water is proposed to involve three intermediates [aryl- or alkenyl-rhodium (oxa-pi-allyl)rhodium, and hydroxo-rhodium] by NMR studies on the rhodium intermediates.
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