Journal
ARCHIVES OF DERMATOLOGICAL RESEARCH
Volume 304, Issue 5, Pages 371-375Publisher
SPRINGER
DOI: 10.1007/s00403-011-1197-x
Keywords
Auto-immune diseases; mir-146a; mir-155; Oral lichen planus; MicroRNAs; miRNAs
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional e Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
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Oral lichen planus (OLP) is a chronic inflammatory disease T helper 1 lymphocytes (Th1)-mediated. Interferon-gamma (IFN-gamma) plays a central role in local immune response in this disease. MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs that have important biological and pathological functions due to their potential mechanism regulating gene expression. Recently, some studies have demonstrated that miRNA-146a and miRNA-155 participate in immune response regulation, and are important in several chronic inflammatory and autoimmune diseases. The purpose of the present study was to investigate the expression of the miRNA-146a and miRNA-155 in 31 OLP lesions compared to normal oral mucosa and blood samples. Quantitative real-time polymerase chain reaction was used to analyze miRNA expressions. Our results showed increased expression of miRNA-146a and miRNA-155 in OLP lesions. In conclusion, these data highlight the possibility of miRNA-146a and miRNA-155 involvement in the regulation of the immune response in OLP.
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