Journal
HIGH PRESSURE RESEARCH
Volume 24, Issue 1, Pages 57-66Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08957950310001635828
Keywords
proteins; pressure; phase diagram; aggregation; fibril formation
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The conditions for temperature and pressure survival of organisms point to proteins as the primary target. The elliptic shape of the stability phase diagram of proteins in aqueous solutions suggests that hydration and packing specificity are important factors. Pressure is a valuable tool for the study of partially unfolded protein conformations that give rise to aggregation and fibril formation.
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