Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 91, Issue 1, Pages 31-36Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2003.11.013
Keywords
Thymus satureioides extracts; triterpenes; flavonoids; topical anti-inflammatory activity; free radical-scavenging effect
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Four extracts at increasing polarity were prepared from the leaves of Thymus satureioides Coss. (Labiatae) and assayed for the in vivo topical anti-inflammatory effect using the croton oil ear test in mice, and for in vitro both antioxidant (DPPHdegrees test) and anti-bacterial (broth microdilution method) activities. The chloroform extract showed a topical anti-inflammatory activity (ID50 = 282 mug cm(-2)), only three times lower than that of the reference drug indomethacin (ID50 = 93 mug cm(-2)) and its active components were identified as ursolic and oleanolic acids. The methanol extract, showing a significant radical-scavenging effect (SC50 = 14.54 mug), was characterized by the isolation and identification of some flavonoids. On the contrary, the extracts did not show any anti-bacterial effect against four standard aerobial bacteria strains. (C) 2003 Published by Elsevier Ireland Ltd.
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