Journal
PARKINSONISM & RELATED DISORDERS
Volume 10, Issue 3, Pages 169-171Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2003.12.002
Keywords
multiple system atrophy; blepharospasm; OPCA; dystonia
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Although blepharoispasm has been occasionally associated with parkinsonism, it has rarely been reported in patients with multiple system atrophy (MSA). We report a 65-year-old woman with MSA who developed blepharospasm seven years after onset, rendering her functionally blind. Clinical course and the findings of magnetic resonance imaging indicated cerebellar type MSA. The blink reflex studies showed prolonged R2 response and enhanced recovery cycle, indicating an increased excitability of the brainstem interneurons. These results suggest that pathophysiology of blepharospasm in MSA is similar to that of essential blepharospasm. Recognition of blepharospasm in MSA patients is important, as blepharospasm is a treatable feature in this otherwise intractable disorder. (C) 2004 Elsevier Ltd. All rights reserved.
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