Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 52, Issue 3, Pages 419-422Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/002215540405200314
Keywords
isoform; epithelial; antibody; tissue
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Funding
- NCI NIH HHS [CA 91341] Funding Source: Medline
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Forty-six advanced-stage human breast carcinoma specimens were evaluated by immunohistochemistry for PKCalpha. expression and compared with 25 samples of normal adjacent breast tissue. For normal tissue, the median staining of ductal epithelia was of moderate intensity. No staining was observed for 67% of tumor specimens, and only 4% showed intensities greater than the median observed in normal tissue. Faint to moderate PKCa staining was observed in the stroma, inflammatory cells, and fibroblasts of tumors but was absent in normal tissue. These findings demonstrate that downregulation of PKCalpha protein occurs in epithelial cells of advanced breast tumors (p<0.001).
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