Journal
NATURE REVIEWS MICROBIOLOGY
Volume 2, Issue 3, Pages 189-202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro840
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Pathogenesis by mycobacteria requires the exploitation of host-cell signalling pathways to enhance the intracellular survival and persistence of the pathogen. The disruption of these pathways by mycobacteria causes impaired maturation of phagosomes into phagolysosomes, modulates host-cell apoptotic pathways and suppresses the host immune response. This review highlights the strategies employed by mycobacteria to subvert host-cell signalling and identifies key molecules involved in these processes that might serve as potential targets for new anti mycobacterial therapies.
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