Journal
JOURNAL OF BIOMECHANICS
Volume 37, Issue 3, Pages 391-400Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0021-9290(03)00252-5
Keywords
cartilage mechanics; biphasic theory; triphasic theory
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Funding
- NIAMS NIH HHS [AR46532, R01 AR046532-05, R01 AR046532] Funding Source: Medline
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Mixture models have been successfully used to describe the response of articular cartilage to various loading conditions. Mow et al. (J. Biornech. Eng. 102 (1980) 73) formulated a biphasic mixture model of articular cartilage where the collagen-proteoglycan matrix is modeled as an intrinsically incompressible porous-permeable solid matrix, and the interstitial fluid is modeled as an incompressible fluid. Lai et al. (J. Biomech. Eng. 113 (1991) 245) proposed a triphasic model of articular cartilage as an extension of their biphasic theory, where negatively charged proteoglycans are modeled to be fixed to the solid matrix, and monovalent ions in the interstitial fluid are modeled as additional fluid phases. Since both models co-exist in the cartilage literature, it is useful to show how the measured properties of articular cartilage (the confined and unconfined compressive and tensile moduli, the compressive and tensile Poisson's ratios, and the shear modulus) relate to both theories. In this study, closed-form expressions are presented that relate biphasic and triphasic material properties in tension, compression and shear. These expressions are then compared to experimental findings in the literature to provide greater insight into the measured properties of articular cartilage as a function of bathing solutions salt concentrations and proteoglycan fixed-charge density. (C) 2003 Elsevier Ltd. All rights reserved.
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