Journal
RNA
Volume 10, Issue 3, Pages 544-550Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.5235104
Keywords
RNA interference; miRNA; miRNP; posttranscriptional gene regulation; translational regulation; mRNA degradation
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Funding
- NIGMS NIH HHS [R01 GM068476, R01 GM068476-01] Funding Source: Medline
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A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this new class of noncoding RNA. Here we show that 2'-O-methyl oligoribonucleotides, but not 2'-deoxyoligonucleotides specifically inactivate the RNAi activity associated with miRNA-protein complexes in human cell extracts as well as in cultured human cells.
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