Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 378, Issue 6, Pages 1594-1600Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-004-2512-6
Keywords
nitric oxide; electrodes array; electrocatalysis; chemically modified electrodes; HUVEC
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In a preliminary study aimed at developing strategies for the simultaneous detection of various biologically important molecules, a procedure is described that allows the electrochemical detection of nitric oxide (NO) released by a population of human umbilical vein endothelial cells (HUVEC) by using an array of electrodes comprising three individually addressable electrodes. Each electrode in the array was modified with a different NO-sensitive electrocatalyst, thereby demonstrating the possibility of modifying the individual electrodes in an array with different sensing chemistries. This study opens a doorway to the development of arrays of electrodes for the simultaneous detection of multiple analytes in a complex environment by suitably tailoring the sensitivity and selectivity of each electrode in the array to a specific analyte in the test medium.
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