Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 122, Issue 3, Pages 820-823Publisher
ELSEVIER SCIENCE INC
DOI: 10.1111/j.0022-202X.2004.22326.x
Keywords
cutaneous lymphoma; Sezary syndrome; Sezary cell; CD158k; KIR3DL2; tumor marker
Categories
Ask authors/readers for more resources
CD158k molecules belong to the family of killer cell immunoglobulin-like receptors (KIR) that are expressed on a minor population of circulating NK and CD8+ T lymphocytes. Here, we report a strong positive correlation between the percentage of CD158k+ blood lymphocytes analyzed by flow cytometry and the percentage of atypical circulating cells (Sezary cells) determined by cytomorphology in a large group of patients with Sezary syndrome. Moreover, we show that circulating CD4+CD158k+ lymphocytes correspond to the malignant clonal cell population. Our findings suggest that the CD158k marker could be a useful tool for the evaluation of the circulating tumoral burden and the follow-up of patients with Sezary syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available