Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 6, Pages 3196-3199Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.6.3196-3199.2004
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Funding
- NIAID NIH HHS [R01AI24345] Funding Source: Medline
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We generated an attenuated, recombinant vesicular stomatitis virus (VSV) expressing high levels of the cottontail rabbit papillomavirus (CRPV) L1 protein from an upstream site in the VSV genome. Rabbits vaccinated once with this VSV-L1 recombinant produced high levels of anti-L1 antibody and were completely protected against papilloma formation after challenge with CRPV. In contrast, animals vaccinated only once with a VSV vector expressing lower levels of L1 from a downstream site in the VSV genome generated lower levels of L1 antibody and demonstrated only incomplete protection from papilloma formation after challenge. We conclude that the level of L1 protein expression is critical in generating complete immunity with a single-dose vaccine.
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