Journal
JOURNAL OF BACTERIOLOGY
Volume 186, Issue 5, Pages 1249-1257Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.5.1249-1257.2004
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Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding. The phenomenon is not restricted to Escherichia coli but can occur in other gram-negative bacteria. Likewise, we show that other short adhesins exemplified by the AIDA-I protein are blocked by the presence of a capsule. The results support the notion that capsule polysaccharides sterically prevent receptor-target recognition of short bacterial adhesins. This negative interference has important biological consequences, such as affecting the ability of bacteria to form biofilms.
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