Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 563, Issue -, Pages 118-124Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2014.07.012
Keywords
microRNA; miR-340; Melanoma; Tumor suppressor; Proliferation; Invasion; RAS; RAF; MAPK
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Funding
- NIEHS [ES007015]
- NIAMS [AR063361]
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microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma. (C) 2014 Elsevier Inc. All rights reserved.
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