Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 558, Issue -, Pages 120-126Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2014.06.022
Keywords
Breast cancer; CD24; CSC; EMT; Notch1
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Funding
- NRF from the Korea Research Foundation [2013-059143]
- Ministry of Education, Science and Technology [2011-K000897]
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We report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. We also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and sternness through Notch1 signaling in breast cancer cells. (C) 2014 Elsevier Inc. All rights reserved,
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