Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 561, Issue -, Pages 109-117Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2014.07.006
Keywords
Angiogenesis; Endothelial cells; Endothelial progenitor cells; VEGF; Osteogenesis; Osteoblasts
Categories
Funding
- University Grant Commission (UGC) Faculty Recharge Programme, Government of India
- [295181]
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Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New blood vessel formation is crucial during both primary bone development as well as fracture repair in adults. Both bone repair and bone remodeling involve the activation and complex interaction between angiogenic and ostegenic pathways. Interestingly studies have demonstrated that angiogenesis precedes the onset of osteogenesis. Indeed reduced or inadequate blood flow has been linked to impaired fracture healing and old age related low bone mass disorders such as osteoporosis. Similarly the slow penetration of host blood vessels in large engineered bone tissue grafts has been cited as one of the major hurdle still impeding current bone construction engineering strategies. This article reviews the current knowledge elaborating the importance of vascularization during bone healing and remodeling, and the current therapeutic strategies being adapted to promote and improve angiogenesis. (C) 2014 Elsevier Inc. All rights reserved.
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