Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 544, Issue -, Pages 58-68Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2013.10.022
Keywords
4-Hydroxyphenylpyruvate dioxygenase; Hydroxymandelate synthase; Oxygenase; Dioxygenase; alpha-Keto acid; Molecular oxygen; Ferrous
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4-Hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate synthase (HMS) are outliers within the alpha-keto acid dependent oxygenase (alpha KAO) family. HPPD and HMS catalyze the chemistry of the majority of enzymes within the alpha KAO family but are clearly mechanistically convergent, having a grossly different structural topology. Some of the unique characteristics of HPPD and HMS have elucidated select parts of the catalytic cycle that are obscured in other family members. Moreover, the inhibitory chemistry of HPPD is a phenomenon with ever-expanding relevance across all kingdoms of life. This review is a synopsis of the literature pertaining to HPPD and HMS. It is not intended as an exhaustive compilation of all observations made for these enzymes but rather a condensed narrative that connects those studies that have advanced the understanding of the chemistry of both enzymes. (C) 2013 Elsevier Inc. All rights reserved.
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