Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 534, Issue 1-2, Pages 3-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2012.10.009
Keywords
Neuronal differentiation; ROS; Oxidative stress; hiPSCs; Modeling diseases; Schizophrenia; Oxygen
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Funding
- National Council for Scientific and Technological Development (CNPq)
- Brazilian Ministry of Health
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- Carlos Chagas Filho Research Support Foundation of the State of Rio de Janeiro (FAPERJ)
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Reactive oxygen species (ROS) and oxygen (O-2) have been implicated in neurogenesis and self-renewal of neural progenitor cells (NPCs). On the other hand, oxidative unbalance, either by an impairment of antioxidant defenses or by an intensified production of ROS, is increasingly related to risk factors of neurodevelopmental disorders, such as schizophrenia. In this scenario, human induced pluripotent stem cells (hiPSCs) emerged as an interesting platform for the study of cellular and molecular aspects of this mental disorder, by complementing other experimental models, with exclusive advantages such as the recapitulation of brain development. Herein we discuss the role of O-2/ROS signaling for neuronal differentiation and how its unbalance could be related to neurodevelopmental disorders, such as schizophrenia. Identifying the role of O-2/ROS in neurogenesis as well as tackling oxidative stress and its disturbances in schizophrenic patients' derived cells will provide an interesting opportunity for the study of neural stem cells differentiation and neurodevelopmental disorders. (C) 2012 Elsevier Inc. All rights reserved.
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