Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging

Objective: This study used diffusion tensor imaging to examine fractional anisotropy in the anterior cingulum and posterior cingulum bundles in patients with schizophrenia. Method: Twenty-one male patients and 20 healthy comparison men were studied. Results: Reduced fractional anisotropy was seen for both sides of the anterior cingulum in the schizophrenia patients, who also exhibited less left-greater-than-right asymmetry in the anterior cingulum than was seen in the comparison subjects. Conclusions: The findings suggest structural disconnections in the anterior cingulum in patients with schizophrenia.