Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 523, Issue 1, Pages 30-36Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2012.01.013
Keywords
Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11
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Funding
- Wisconsin Alumni Research Foundation
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Bioactivation of vitamin D-3 involves 25-hydroxylation and subsequent 1 alpha-hydroxylation to produce 1 alpha,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3], the active hormone. six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed. (C) 2012 Elsevier Inc. All rights reserved.
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