Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 519, Issue 2, Pages 194-201Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2011.09.012
Keywords
Phenylalanine hydroxylase; Allostery; Regulation; Phosphorylation; Tetrahydrobiopterin
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Funding
- NIH [GM047291, GM098140]
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The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme. (C) 2011 Elsevier Inc. All rights reserved.
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