Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 507, Issue 1, Pages 194-203Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.09.026
Keywords
P450; Plant secondary metabolism; Isoquinoline alkaloids; Oxidative rearrangement; Methylenedioxy bridge; Phenol coupling
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21248013]
- Grants-in-Aid for Scientific Research [21248013] Funding Source: KAKEN
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Plant cytochromes P450 (P450s) participate in a variety of biochemical pathways to produce a vast diversity of plant natural products. The number of P450 genes in plant genomes is estimated to be up to 1% of the total gene annotations of each plant species, implying that plants are huge sources for various P450-dependent reactions. Plant P450s catalyze a wide variety of monooxygenation/hydroxylation reactions in secondary metabolism, and some of them are involved in unusual reactions such as methylenedioxy-bridge formation, phenol coupling reactions, oxidative rearrangement of carbon skeletons, and oxidative C-C bond cleavage. Here, we summarize unusual P450 reactions in various plant secondary metabolisms, and describe their proposed reaction mechanisms. (C) 2010 Elsevier Inc. All rights reserved.
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