Journal
BIOESSAYS
Volume 26, Issue 3, Pages 221-224Publisher
WILEY
DOI: 10.1002/bies.20017
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The highly homologous Rac1 and Rac2 GTPases are co-expressed in cells of haematopoletic origin and are likely to show some functional redundancy. While disruption of the Rac2gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles (1,2) have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity. BioEssays 26: 221-224, 2004. (C) 2004 Wiley Periodicals, Inc.
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