Journal
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
Volume 7, Issue 1, Pages 1-14Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10253890310001650268
Keywords
ACTH; adjuvant-induced arthritis; corticotropin-releasing hormone; glucocorticoids; multiple sclerosis; neuropathy
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Hypothalamo-pituitary-adrenal (HPA) axis changes have been reported in several disease states, including major depressive disorder, rheumatoid arthritis, multiple sclerosis and various other conditions associated with chronic pain. These observations suggest that stress and the HPA axis may play important roles in the pathology of these diseases. In order to contribute to a better understanding of the role that chronic stress may play in human pathology, this review article explores the involvement of the HPA axis in those animal models of chronic pain and inflammation that entail persistent rather than intermittent stress.
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