Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 510, Issue 2, Pages 93-100Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2011.04.003
Keywords
Kinases; Phosphatases; Cilia; Flagella; Axoneme
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Funding
- NIGMS NIH HHS [R01 GM051173, R37 GM051173, R37 GM051173-27] Funding Source: Medline
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Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates. (C) 2011 Elsevier Inc. All rights reserved.
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