Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 502, Issue 2, Pages 137-143Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.08.001
Keywords
Selenoprotein K; Endoplasmic reticulum stress; siRNA; Apoptosis
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Funding
- National Natural Science Foundation of China [30870555]
- Specialized Research Fund for the Doctoral Program of Higher Education
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Selenoprotein K (SelK), an endoplasmic reticulum (ER) resident protein, its biological function has been less-well studied. To investigate the role of SelK in the ER stress response, effects of SelK gene silence and ER stress agents on expression of SelK and cell apoptosis in HepG2 cells were studied. The results showed that SelK was regulated by ER stress agents, Tunicamycin (Tm) and beta-Mercaptoethanol (beta-ME), in HepG2 cells. Moreover, the SelK gene silence by RNA interference could significantly aggravate HepG2 cell death and apoptosis induced by the ER stress agents. These results suggest that SelK is an ER stress-regulated protein and plays an important role in protecting HepG2 cells from ER stress agent-induced apoptosis. (C) 2010 Elsevier Inc. All rights reserved.
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