Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 501, Issue 1, Pages 79-90Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.05.003
Keywords
Polyphenols; SIRT1; Oxidants; Resveratrol; Inflammation
Categories
Funding
- NIH [1R01HL085613, 1R01HL097751, 1R01HL092842]
- NIEHS Environmental Health Science Center [P30-ES01247]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL092842, R01HL097751, R01HL085613] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES001247] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging, inflammation-immune function, endothelial functions, and circadian rhythms. Naturally occurring dietary polyphenols, such as resveratrol, curcumin, quercetin, and catechins, have antioxidant and anti-inflammatory properties via modulating different pathways, such as NF-kappa B- and mitogen activated protein kinase-dependent signaling pathways. In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models. Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction. In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available