Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 501, Issue 1, Pages 151-157Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.05.019
Keywords
Anthocyanidins; Colon cancer cells; Cytotoxicity; Apoptosis; Oxidative stress; Glutathione
Categories
Funding
- Ministero degli Affari Esteri
- Ministero dell'Universita e Ricerca [PRIN 20084TASKL_005]
Ask authors/readers for more resources
Colorectal cancer is the second most frequent cause of cancer death in the western world. Although the prognosis has improved after the introduction of newer anticancer drugs, the treatment of metastatic colorectal cancer still remains a challenge due to a high percentage of drug-resistant tumor forms. We aimed at testing whether anthocyanidins exerted cytotoxicity in primary (Caco-2) and metastatic (LoVo and LoVo/ADR) colorectal cancer cell lines. Both cyanidin and delphinidin, though neither pelargonidin nor malvidin, were cytotoxic in metastatic cells only. The cell line most sensitive to anthocyanidins was the drug-resistant LoVo/ADR. There, cellular ROS accumulation, inhibition of glutathione reductase, and depletion of glutathione could be observed. This suggests that anthocyanidins may be used as sensitizing agents in metastatic colorectal cancer therapy. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available