Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 500, Issue 2, Pages 116-122Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.05.012
Keywords
GST; MDR; MAPK; Pro-drug; Inhibitor
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Chemoresistance is a multifactorial phenomenon and many studies clearly show that a coordinated expression of efflux transporter proteins and phase II conjugating enzymes in tumor cells is linked to the development of the multidrug resistance phenotype. In particular, the overexpression of glutathione S-transferases and efflux pumps in tumors may reduce the reactivity of various anticancer drugs. In recent years it has become evident that glutathione S-transferases are also involved in the control of apoptosis through the inhibition of the JNK signaling pathway. As such, the glutathione S-transferase superfamily has become the focus of extensive pharmaceutical research in attempt to generate more efficient anticancer agents. Here we present an overview of the GST inhibitors and the GST-activated pro-drugs utilized to date to overcome drug resistance. (C) 2010 Elsevier Inc. All rights reserved.
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