Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 503, Issue 1, Pages 28-34Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2010.07.020
Keywords
Bone marrow; Osteoclast; Osteoblast; Stem cell; Niche
Categories
Funding
- Ministry of Health Rare Diseases [GGP06019, GGP09018]
- E-rare
- Fondazione Telethon Funding Source: Custom
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Interplays between bone and bone marrow are not limited to merely anatomic and histological connections, but include a tight functional correlation. Bone marrow resides within the medullary cavity of the bones and the process of hematopoiesis is regulated, at least in part, by bone cells. Moreover, osteoclasts and osteoblasts derive from precursors of hematopoietic and mesenchymal origin, respectively, both residing within the bone marrow. Alterations in one of these components typically cause impairment in the other, so diseases of the bone marrow compartment often affect the bone and vice versa. All these findings could make us to speculate that bone and bone marrow are not two separate districts, but can be considered as the two elements of the same unique functional unit, the bone-bone marrow organ. Here we will describe histological and functional interplays between bone and bone marrow, and will illustrate some diseases in which this tight correlation is evident. (C) 2010 Elsevier Inc. All rights reserved.
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