Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 51, Issue 3, Pages 452-457Publisher
WILEY
DOI: 10.1002/mrm.10730
Keywords
MRI; Alzheimer's disease; mouse; amyloid; plaque; microimaging
Funding
- NCRR NIH HHS [P41 RR15241] Funding Source: Medline
- NIA NIH HHS [AG15490] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909] Funding Source: Medline
- NICHD NIH HHS [R03 HD37931] Funding Source: Medline
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We performed three-dimensional, high-resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque-like structures in the cortex and hippocampus could be clearly identified in T-2-weighted images with an image resolution of 46 mum x 72 mum x 72 mum. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red-stained histological results. This technique is quantitative, less labor-intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD). (C) 2004 Wiley-Liss, Inc.
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